September 7, 2017
This article originally appeared on The Body.
Overall cancer risk was 69% higher with HIV than in the general U.S. population in 1996-2012, according to an analysis involving 448,258 HIV-positive people. HIV conferred a higher risk of AIDS-defining cancers, most non-AIDS virus-related cancers and a few non-AIDS virus-unrelated cancers, including lung cancer.
Higher cancer risk with HIV reflects impaired immune control of cancer-causing viral infections, as well as lifestyle factors such as smoking and alcohol use. National Cancer Institute (NCI) researchers who conducted the new study note that wider and earlier use of antiretroviral therapy (ART) might lower the risk of some cancers but may not completely reverse the impact of early immunosuppression and ongoing immune dysfunction and inflammation. Because few recent population-based studies address relative cancer risk with HIV, these investigators analyzed HIV-related cancer incidence over time by matching population-based HIV and cancer registries.